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Nature 610:783790 Lardhi A, Ali RA, Ali R, Mohammed T (2018) Thalassemia minor presenting with vitamin B12 deficiency, paraparesis, and microcytosis
That's where most protocols start, but the preparation method

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So, if your vitamin B12 deficiency is due to an autoimmune disease in which your stomach doesn't make intrinsic factor, supplements might not work for you, and you will need injections
It would happen a few hours after an injection, but only once or twice, then it would return to normal