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26 This idea essentially demonstrates how a cell changes throughout development from an undifferentiated state to one of several distinct, individual, differentiated cell fates, which are controlled by epigenetic mechanisms (Fig
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The occurrence and development of cancer are closely related to oxidative stress and inflammatory response, which not only promote the proliferation and metastasis of cancer cells, but also lead to damage to normal tissues (106)
Thereby, large amount of lipid peroxide, such as Malondialdehyde (MDA), hydroxyl, carbonyl, etc., will cause cell death, which leads to neuronal apoptosis ultimately (Wu et al., 2009

Glutaric aciduria type II: treatment with riboflavine, carnitine and insulin
