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Assessing the degree to which cognitive dysfunction is caused by hepatic insufficiency can be challenging, as not only can a multitude of potential concurrent factors such as infection, renal failure, drugs, or pre-existing cognitive/psychiatric disorders contribute to and exacerbate HE, but causes of underlying liver disease such as alcohol [25], obesity [26] and Hepatitis C [27] may also lead to impairment in cognitive ability

Additionally, TMAO is closely associated with neurological disorders (Parker et al., 2020)

[DOI] [PubMed] [Google Scholar] 72.Flodin N.W

Amyloid- induces lipid droplet-mediated microglial dysfunction via the enzyme DGAT2 in Alzheimers disease