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NNMT plays a crucial role in metabolism and energy, primarily in fat tissue
[1] Because intrinsic-factor-dependent uptake in the distal ileum can be absent in conditions such as autoimmune gastritis, pancreatic insufficiency, or bariatric surgery, the intramuscular or subcutaneous route bypasses gastrointestinal barriers and reliably restores serum concentrations
Spence Clin Chem Lab Med 2013)
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