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Compounds spanning 100-fold IC50 values for NNMT inhibition were selected on the basis of positional substitutions around the N-methylated quinolinium scaffold to obtain an estimate of drug-like oral absorption/bioavailability properties and guide the choice of inhibitors for in vitro and in vivo phenotypic studies

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Two patient groups were compared, those who had micronutrient deficiencies repleted prior to surgery (Group A, n=42), and those who entered surgery with a known micronutrient deficiency (Group B, n=38)