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To be used for the experiments, the lyophilized powder was initially dissolved in NH 3 OH 6 M to obtain a stock solution with a final concentration of 250 M

It is located in the outer surface of plasma membranes of epithelial cells and cleaves the extracellular GSH to glutamate and cysteinyl-glycine, which is subsequently hydrolyzed by a dipeptidase to yield the constituent amino acids[37]

Taofiq O, Gonzlez-Params AM, Martins A, et al

Destro et al., 2010)

Figure 4 4 Therapeutic strategies targeting ferroptosis in Alzheimers disease 4.1 Therapeutic strategies targeting iron homeostasis In AD, the disruption of iron homeostasis is considered a pivotal upstream event that triggers ferroptosis activation and drives pathological spread (Figure 5)