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Additionally, regular cell culture conditions using room air represent hyperoxic conditions for these cells, which are known to result in increased ROS formation
The vulnerability of mtDNA to insult, coupled with its bacterial-like molecular patterns, makes it a central actor in the cycle of metabolic failure and immune dysfunction that characterizes HIV infection

CaladaDVianelloDGiampieriESalaCCastellaniGde GraafAet alThe role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

S2CID 31973969.
