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Cells 10 , 141 (2021)

The clinical diagnosis is suspected in a patient with fever, abdominal pain, and jaundice (the Charcots triad)

X-ray crystallographic and kinetic correlation of a clinically observed human fumarase mutation
Due to their high chemical reactivity, ROS can oxidize a wide array of biomolecules, potentially altering their structure and impairing function [3]

Furthermore, several other intermediate compounds, such as folic acid and enzymes like methyl tetrahydrofolate reductase (MTHFR), influence the availability of cysteine and further taurine synthesis, which are all affected by exercise-induced ROS generation ( Does Taurine Regulate Mitochondrial ROS Production in Overused Muscle
