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O., Rigoldi Bonjardim L., Csar Rodrigues Conti P., and StuginskiBarbosa J., Awake Bruxism Onset and Exacerbation Associated With Lisdexamfetamine Dimesylate Intake: Insights From 2 Case Reports, Journal of Clinical Psychopharmacology 45 (2025): 401404

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Yes, they are both used by people trying to optimize their health, but they act on entirely different systems for entirely different reasons

These coactivators generally orchestrate with DNA-bound transcription factors, such as nuclear respiratory factors (NRF1, NRF2), estrogen-related receptors (ERR, ERR, and ERR), and myocyte enhancer factor 2 (MEF2) to drive the expression of target genes