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Although immunogenicity to biologics is often not directly associated with adverse events in animal models, these studies have limited predictive power for the immunogenicity of the biologic in humans

Although the BB-50 brush-border antigen was also localized in peritubular capillaries (Mutti et al., 1985), subsequent work lead to the identification of a monoclonal antibody reacting with an antigen located specifically in the brush border and thus called BBA or brush-border antigen (Mutti et al., 1988)

In the Phase 2/3 portion of Study 2, based on data accrued through November 14, 2020, approximately 44,000 participants 12 years of age and older were randomized equally and received 2 doses of Pfizer-BioNTech COVID-19 Vaccine (30 mcg modRNA) or placebo separated by 21 days