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4 Neuro-inflammation, Neurotoxicity and Cognitive ImpairmentA Longer-Term Scenario In addition to the development of addiction, long-term methamphetamine use drives multiple pathways including inflammation, oxidative stress and apoptosis that in concert lead to neurotoxicity (Box 3)

doi: 10.1105/tpc.109.071225

Detoxification Supports liver function and eliminates toxins from the body

Consistent with its gastrointestinal expression, FXR plays important roles in the regulation of enterohepatic cycling of bile acids, feedback regulation of bile acid biosynthesis, and protection against bile acid-associated toxicity

it supports cellular functions that may be relevant to exercise, hydration, cardiovascular support, and recovery-oriented formulas