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Inoculation with IcL also induced secretion of some proinflammatory cytokines including KC which regulates leukocyte migration and is mostly involved in repair and healing, contributing to clearance of bacteria at early stages of infection

Mantaj J, Rahman SA, Bokshi B, Hasan CM, Jackson PJ, Parsons RB, Rahman KM (2015) Crispene E, a cis-clerodane diterpene inhibits STAT3 dimerization in breast cancer cells

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Even Avecho Biotechnology (formerly Phosphagenics), a company who wanted to repurposed AOD-9604 as a transdermal formulation, knew why the clinical trials failed: AOD9604s delivery could have been the key issue