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T., Snizhko D

(2019) 29:13761389.e4

NA cannot be salvaged into NAD + any longer if it is N-methylated by NNMT, so the methylation of NA impairs the abundance of free NAD + and then affects the activities of these NAD + -consuming enzymes [19]

Front Pharmacol 8:412 Coutinho A (2012) Honeybee propolis extract in periodontal treatment: a clinical and microbiological study of propolis in periodontal treatment

It means that the efficacy of monotherapy could be offset by other signaling pathways
