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The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH Abbreviations Met L-methionine Cys L-cysteine Hcy L-homocysteine SAA Sulfur-containing amino acids CBS Cystathionine -synthase CSE Cystathionine -lyase CDO Cysteine dioxygenase CSD Cysteinesulfinate decarboxylase Footnotes Competing interest: none declared

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The maximal activity of the dimeric macrocycles was observed at around 100 nM

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