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The alpha7nACh-NMDA receptor complex is involved in cue-induced reinstatement of nicotine seeking

Mechanisms of OR desensitization OR phosphorylation Numerous studies have been carried out to demonstrate the role of OR phosphorylation in desensitization by using chemical inhibitors of kinases, in vitro or in vivo knock-out (KO) of kinases using siRNA or transgenic mice, over-expression of dominant negative mutants of kinases, amino acid substitution or truncation on OR

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Pickova D, Ostry V, Toman J, Malir F