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Description
Arthritis Rheum: Official Journal of the American College of Rheumatology (2006) 54:152935

An NHL variant containing a Michael acceptor can be used to trap deubiquitinases (DUBs) and ubiquitin-carrying enzymes
Results showed that disease suppression increased with increased liming rates

During the process of correct protein folding in the ER, the PDI enzymes catalyze disulfide bond isomerization and reduction which aids in correct protein folding
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