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Molecules such as fibroblast growth factor 21 (47), BCL2 interacting protein 3/NIP3-like protein X (48) and acteoside (via the NRF2-mitophagy axis) (49) mitigate ferroptosis by restoring mitochondrial function or removing damaged mitochondria, underscoring the protective role of mitophagy against ferroptosis

Thus, aerobic exercise, resistance training, and HIIT each provide distinct advantages and can collectively form a comprehensive fitness program