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And if you've celebrated your 50th birthday, your body naturally becomes less efficient at extracting B12 from food just one of those unwelcome aging "perks" we all look forward to

Hallur M

This can be due to COMT, MTR or MTRR genetic mutations which help the body convert B12 into its active forms for use at the enzymatic and cellular level

10.1261/rna5160904 106 PiazzollaG.CandigliotaM.FanelliM.CastrovilliA.BerardiE.AntonicaG.et al (2019)

When NNMT is overactive, less nicotinamide is available for recycling, and cellular NAD+ levels fall
