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They need to be present consistently to maintain the gene expression changes that drive collagen synthesis
Furthermore, melatonin suppresses MPP-induced activation of the NLRP3 inflammasome, thereby preventing neuronal degeneration and microglial activation, and ameliorates motor symptoms in PD mice [194, 195]
[Google Scholar] Mullins P
Pickart and Margolina's review provides the broader gene expression context for why these effects occur
J Proteomics 75(6):17521763
