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In 2013, a double-blind randomized controlled study was sponsored by Edison Pharmaceuticals to evaluate the safety and efficacy of EPI-743 in FRDA patients (Zesiewicz et al., 2018b)

10.1126/science.182.4115.929

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In particular, AR signaling influences the fates of citrate that uniquely characterizes normal and malignant prostatic metabolism (i.e., mitochondrial export and extracellular secretion in normal prostate, mitochondrial retention and oxidation to support oxidative phenotype of primary PCa, and extra-mitochondrial interconversion into acetyl-CoA for fatty acid synthesis and epigenetics in the advanced PCa)