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Luka Z, Pakhomova S, Loukachevitch LV, Calcutt MW, Newcomer ME, Wagner C

Apatinib combined with s-1 therapy was superior to s-1 alone in the second-line treatment of GC

In the Billon 2023 paper, mice given 30 mg/kg IP still showed measurable plasma and muscle concentrations at 6 hours post-injection, which helps explain why twice-daily dosing was used in efficacy studies

The range is shown in the graphs below

Representative traces of I SK1-3 at +80 mV in absence (Ctr) or presence of SKF38393 (SKF, 10 M for 1 h) or fenoldopam (Fen, 5 M for 1 h) or SKF38393 plus SCH23390 (SKF+SCH) or fenoldopam plus SCH23390 (Fen+SCH)