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Clinically, men may present with gynecomastia, testicular atrophy, decreased libido, erectile dysfunction, and feminization, while women may experience menstrual irregularities, anovulation, or infertility

292 Reduced membrane-associated RING finger protein 2 (March 2) disrupts its interaction with PKM2, altering glucose metabolism and increasing lactate production, which enhances H3K18la and p53-mediated apoptosis in VSMCs, worsening aortic aneurysm/dissection

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Patients with suspected IE referred to our echocardiography laboratory from September 2021 to June 2022 were enrolled