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Sustained activation of the PERK-eIF2 pathway promotes increased expression of ATF4, which, besides its role in ERS-mediated apoptosis regulation, can bind to promoter regions of necroptosis-related genes, regulating their transcriptional activity and affecting necroptosis (Iurlaro and Muoz-Pinedo, 2016)

Moreover, in specific context, p75 NTR can activate TrkB-independent pro-survival signals, which involve activation of transcription factor NF-B and PI3K/Akt pathway 4,5