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The gut microbiota plays a pivotal role, producing metabolites and neurotransmitters that influence brain function via the vagus nerve and enteric nervous system, while the hypothalamicpituitaryadrenal (HPA) axis modulates stress responses, impacting both gut and brain functions (Yang et al., 2018

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Melanocytes use an enzyme called tyrosinase to convert the amino acid tyrosine into eumelanin, which is a dark brown pigment

These disruptions include glucose metabolic disorders characterized by IR, sexual hormone metabolic disorders dominated by hyperandrogenism, abnormal bile acid metabolic pathways, IL-22 mediated intestinal immune dysfunction, and dysregulation of the brain-gut axis

[DOI] [PMC free article] [PubMed] [Google Scholar] 56.Gage MJG, Macfariane CP, Yeates S, Ward RG, Searle JBPG