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Following activation of glutamate receptors, mitochondrial respiratory chain defects along with calcium overload and ROS accumulation seem to be the major routes that are induced, allowing the stimulation of apoptosis (91,92)

The results of the meta-analyses show that resistance training programs increase BMD when applied for 6 months [46], combined with high-impact or weight-bearing exercises [43], or in patients with osteoporosis and osteopenia [47]

doi: 10.1016/j.hcl.2013.04.002

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