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BioMedicine 6, 20
Predicted glutathione and substrate binding sites are shaded in black and gray, respectively
In colorectal cancer patients, co-treatment with Manuka honey (UMF 15+) and 5-fluorouracil (5-FU) increased intratumoral drug concentration by 62%, attributed to inhibition of efflux transporters such as P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) (135)
R.LoRussoP.ShapiroG.et al (2011)
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