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Despite maintaining lower levels of gluconeogenesis compared to wild type counterparts (Fig

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Intestinal microbes in the large intestine have choline trimethylamine (TMA)-lyase (CutC), which can break the CN bonds in nutrients to produce the tasteful TMA gas ( Plasma TMAO levels in healthy humans are about 0.55.0 M ( The Metabolism of TMAO TMAO is a small molecule compound and is, therefore, easily filtered by the kidneys ( FMO3 is the key enzyme for the transformation of TMA to TMAO in the liver, and its transformation efficiency is the highest

However, taking more than the recommended dose does not necessarily accelerate the benefits