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While the KCH criteria had excellent specificity, it was at the expense of sensitivity, yielding a limited ability to distinguish patients who would survive with conservative medical management versus those that would die without a liver transplant

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However, many of the preliminary studies were carried out when the circulating virus was more antigenically similar to the vaccine immunogen (typically from the Wuhan-Hu-1 variant of SARS-CoV-2) than is now the case

A randomized placebo-controlled trial of rasagiline in levodopa-treated patients with Parkinson disease and motor fluctuations: the PRESTO study