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qRT-PCR analysis revealed that treatment with K-Hcy-modified recombinant HMGB1/2 significantly upregulated both SASP markers and MARS1 expression in HCMECs, suggesting a potential HMGB1/2 K-Hcy -MARS1-driven positive feedback loop and an intensified paracrine senescence signaling cascade (Figure 6C-D)

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Paumi CM, Ledford BG, Smitherman PK, Townsend AJ, Morrow CS

Addressing Underlying Triggers and Factors Identifying potential triggers and eliminating them from the childs sleep environment can reduce the frequency of night terrors in toddlers

Regarding CSSS, there was a significant decrease in CSSS in all studied patients after intervention (the range decreased from an initial of 19118 to 1099 after intervention with a P-value of 0.025)