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Interestingly, the growth of tumour xenografts formed by ABCB1/MDR1-overexpressed MDR uterine sarcoma and breast cancer cell lines, knocked down for MET with shRNA, was reduced compared to tumours formed by control shRNA transfected cells [33]

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Together, the new findings suggest that when too much B12 is present, the bacteria have changes in their gene expression that suppress further synthesis of the vitamin

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