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Infection also represents an important source of pain, and any sudden onset, change in character, or increase in intensity should raise suspicion of infectious complications [30]

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A similar line of reasoning involves the kidney in the manifestations of the high-folatelow-vitamin B-12 interaction: depletion of serum vitamin B-12 may also be the result of preferential uptake of folic acid into the renal proximal tubule cells via FR-

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