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Together with our previous findings 16 , we demonstrate that GCGR blockade not only induces -cell hyperplasia but also increases glucagon expression and secretion at the single-cell level

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A chronic wound is defined as a wound that does not heal in the orderly stages of the healing process, does not heal within three months or is 4050% unhealed after four weeks of appropriate treatment [5]

Peer review Peer review information Nature Medicine thanks Christiana Kartsonaki, Peter Rossing, Naveed Sattar and Vikas Sridhar for their contribution to the peer review of this work