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TRT is often a lifelong treatment

While some patients report vasomotor symptoms during treatment, there is no established pharmacological mechanism directly linking tirzepatide to hot flashes

10.1016/j.jconrel.2011.09.083 15 ArafaM

HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation

Here are some of the most notable trials and experiments outlining the peptides potential: According to Kastsiuchenka et al