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On the other hand, also in the extracellular space, the cysteinyl-glycine fraction is split by the enzyme dipeptidase generating cysteine and glycine
Stojanovic, O
Zalba S, Ten Hagen TL
Although a decrease in circulating and skeletal muscle IGF-1 has been reported in various chronic conditions, including cancer, congestive heart failure, chronic kidney disease, and COPD, and aging [5,163] (Figure 2), more studies are required to determine whether IGF-1 administration could be a therapeutic approach to treat muscle atrophy in these patients (discussed below)
Weinreb O, Amit T, Mandel S, Youdim MB
