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In addition, nuclear receptors such as the farnesoid X receptor (FXR) and liver X receptor sense bile acid and cholesterol levels to regulate cholesterol transport, lipid synthesis, and inflammatory responses, thereby playing critical roles in lipid metabolic regulation along the gutliver axis (33)

It is commonly used to manage conditions related to fatigue, neuropathy, and vitamin deficiencies

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Abbreviations VPA: Valproic acid ICU: Intensive care unit SAPS II: Simplified Acute Physiology Score II SOFA: Sequential Organ Failure Assessment t 1/2 : Elimination half-life References Methaneethorn J
