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While these studies involve relatively small groups of participants, their scientific and operational complexity is considerable

Interestingly, the actions mentioned above of GR may be modulated by other nuclear receptors specific for certain endocrine tumours, such as androgen receptors (ARs), estrogen receptors (ERs), or progesterone receptors (PRs)

Furthermore, Fe 3 O 4 reacts with hydrogen peroxide, leading to a Fenton reaction, followed by the overproduction of hydroxyl radicals, which increases ROS levels and further induces ferroptosis in cells ( The second category of ferroptosis-related nanodrugs (for inhibiting intracellular GPX4 activity): In addition to promoting the intracellular Fenton reaction, these nanodrugs can inhibit GPX4 activity, thus reducing intracellular GSH levels

Klimentova J, Cebova M, Barta A, Matuskova Z, Vrankova S, Rehakova R, et al

During treatment of pulmonary fibrotic rats with EGCG, the rats exhibited reduced inflammation, alveolar damage, and vascular congestion, which were associated with the membrane-stabilizing and antioxidant properties of EGCG, demonstrating that EGCG can act as a potential anti-fibrotic drug (73)