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A hybrid quantum mechanics/molecular mechanics (QM/MM) method was established to model the reaction energies of each cysteine with H 2 O 2 (Supplementary methods) According to this method, the activation energy ( E a ) for oxidization of deprotonated GLRX cysteine residues follows the following trend: E a (C8) E a (C83) Ser (15.977 Da (C) and S-glutathionylation (+305.068 Da)

One of the oxidants capable of inducing the release of Zn from MTs is nitric oxide (NO)

This allows the nutrient to be delivered directly to the cells that need it most, mimicking the body's natural way of transporting molecules

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