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33 Understanding the etiological contributors to such donordependent variance might shed light not just on RBC storage biology, but also contribute significantly to our understanding of those pathologies associated with RBC hemolysis due to exacerbated oxidant stress (e.g., sickle cell disease, b-thalassemia, pulmonary hypertension, Down syndrome, inflammaging 39 )

doi: 10.1038/ng1244

Tissue Preparation Organ tissue was fixed in 10% neutral buffered formalin (pH 7.4) at room temperature for 24 h (brain, liver, kidney, lungs, heart, stomach, intestines)

Unc5 regulates axon guidance in many species and a member of its family, Unc5B is found in ECs of humans [249]
