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Elevated copper in Alzheimers disease has also been widely reported 42 , although evidence exists to show that while elevated copper is associated with plaques 43 , brain copper levels more broadly are decreased 44,45 and improving copper bioavailability can ameliorate pathology in a mouse model of disease 46,47

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Skin homeostasis plays an important role in the development of AD

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It was reported that agmatine could resist inflammation, apoptotic, and oxidant

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Mood Regulation: Reduces symptoms of anxiety and stress, providing a more stable emotional state which is conducive to sustained mental activity

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FIGURE 3 Cerium oxide (CeO 2 ) NPs, where Ce as a rare chemical element can exist in two valence states (i.e., oxidized Ce 4+ and reduced Ce 3+ ), possess excellent ROS scavenging capability (like SOD and CAT enzymes) and relieve the oxidative stress in disease sites (Kim et al., 2019)

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