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10.1016/j.scitotenv.2019.134406 23 LiuT.LiN.ZhuJ.YuG.GuoK.ZhouL.et al (2014)

Because it took nearly 15 years to secure permits for design, the design team (led by Frank Pont) took years to refine the somewhat complex design concept of a reversible course, following an idea proposed by Tom Simpson some 90 years ago

165 An open-label phase followed the placebo control phase in this trial
