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But excessive or prolonged inflammation becomes destructive

Recently, it has been demonstrated that the mechanism of acquired bortezomib resistance is due to the high levels of the GSTP enzyme produced under oxidized conditions [128]

10.1371/journal.pone.0171279 PLoS One 4 ArnoldA

Changes in both trans- and cis-regulatory elements mediate insecticide resistance in a lepidopteron pest, Spodoptera exigua

This poses significant challenges for the long-term success of gene therapy, mainly in patients receiving low doses of AAV, such as children, as tissue growth and proliferation may dilute the vector genome, potentially worsening symptoms over time