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In a phase II open label trial, there were improvements in gait velocity, memory, and breathholding

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Pyruvate supplements have been promoted for weight loss, boosting athletic performance, and lowering cholesterol

Specific strains such as Bifidobacterium lactis and Bifidobacterium bifidum have been documented to improve tear secretion and BUT ( Saccharomyces boulardii MUCL 53837 and Enterococcus faecium LMG S-28935 have been effective in alleviating subjective symptoms of DED ( Bifidobacterium and Lactobacillus plantarum not only increased tear secretion but also repaired CECs and reduced inflammatory markers like TNF- and IL-1 (Yun et al., 2021)

When used on the face, it can sometimes cause raw, irritated skin or other side effects