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In addition, several GPX4-independent anti-ferroptosis pathways have recently been identified, such as the apoptosis-inducing factor mitochondria-associated 2 (AIFM2)-mediated CoQ10 production pathway ( FIGURE 1 Lipid peroxidation results in the oxidation of polyunsaturated fatty acid (PUFA) of the membrane lipids

Thus, ensuring adequate amino acid availability for fish can enhance immune resilience and improve survival rates under stressful aquaculture environments

While resmetirom remains the only FDA-approved therapy to date, experimental agents such as elamipretide (SS-31) and uncoupling protein 2 (UCP2) modulators are under investigation to restore mitochondrial integrity and reduce ROS production [103106]