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In general, mitochondrial biogenesis coupled with dynamic fusion and fission maintain healthy mitochondria, whereas damaged mitochondria are degraded by mitophagy (Michel et al., 2012)

1) Heart Disease In a meta-analysis of 19 studies with almost 20,000 people, high TMAO levels were associated with increased rates of cardiovascular diseases , such as heart failure and stroke

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It also decreases mitochondrial energy, which slows down motility