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This epigenetic reprogramming primarily occurs through DNA methylation, histone modifications, and non-coding RNA regulation (Figure 4)
Wang WZ, Jones AW, Wang M, Durante W, Korthuis RJ
In patients taking opioids for an extended periods of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see Dosage And Administration, and Warnings]
2023;56:32035.e329
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