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The protocol successfully generated hepatocytes from cGMP cell lines using small molecules combined with growth factors in 21 days ( ALB expression was detected but insignificant in the induced hepatocytes, suggesting that the hepatocytes was immature ( ALB positive hepatocytes account for 67.7% versus 37.1% in the growth factor group ( 3.2 Small molecules for direct reprogramming to hepatic lineage Recently, studies have shown that somatic cells can be directly reprogrammed into specific cell lineage, including hepatocytes

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Moreover, we summarize the clinical manifestations, treatment, prognosis, and genetic characteristics of patients with GSSD reported in China to date

Reyes-CamachoDVinyetaEPerezJFAumillerTCriadoLPaladeLMet al

This unexpected effect of PQQ was reversed by catalase, indicating that it completely eradicated the production of H 2 O 2 during PQQ autoxidation in the culture medium