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The differences in the clinical presentation are most likely due to the fact that some degree of IGF-I production is present in patients with GH deficiency, GHR, and GHRH defects

These ROS are oxygen free radicals produced by the reduction in molecular oxygen and generated as byproducts of aerobic respiration and metabolism

[PubMed] [Google Scholar] 57.Gonzalez A., Walsh A., Ratamess N., Kang J., Hoffman J