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12.2.1 Potential synergistic effects In some preclinical studies, curcumin has shown the ability to enhance the efficacy of certain chemotherapeutic agents (e.g., paclitaxel, gemcitabine, cisplatin) by sensitizing cancer cells to the drugs, inhibiting drug resistance, and promoting apoptosis

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(6) Therapeutic efficacy is highly time sensitive, with optimal outcomes occurring prior to completion of the aging process and markedly reduced oxime responsiveness after the post-aging window

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PPAR co-association with transcription factor NFAT