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There's no chemical incompatibility between GHK-Cu and retinol - they work through entirely different pathways - but if your skin is sensitive or you're new to one or both, give them separate evenings until you know how your skin responds

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[DOI] [PubMed] [Google Scholar] 106.Ung D., Nagar S

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In insulin-resistant states, PI3K/Akt and NFB pathways serve as major downstream effectors of AGERAGE signaling

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doi: 10.1016/j.placenta.2004.01.011

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