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Animal models have demonstrated increased ammonia levels lead to intracellular production of reactive oxygen species, induction of cellular apoptosis in bovine epithelial cells, increased inflammatory cytokines and repression of DNA repair-related genes in porcine Type II alveolar epithelial cells 48, 49

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Interactions between c-MET II and HGF I Distinct to the binding mode between c-MET I and HGF I that involves multiple domains of HGF, only the K1 domain located on the opposite side of HGF I makes direct contact with c-MET II, indicating that HGF-K1 is essential for c-MET activation (Fig

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[DOI] [PubMed] [Google Scholar] 86.Barutta F, Bruno G, Mastrocola R, et al

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Glutamine-dependent -ketoglutarate production regulates the balance between T helper 1 cell and regulatory T cell generation

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